Because the ICHD stipulates that the essential diagnostic criteria of migraine and many other headache disorders are based mainly on clinical features, with no decisive pathological or radiological finding, the concept of a probable diagnosis seems to be indispensable in making a headache diagnosis.
Traditionally, epidemiological studies have used broad categories defined mainly by clinical features: Hodgkin lymphoma, non-Hodgkin lymphoma (NHL), leukaemia, and multiple myeloma.
Although Dubowitz syndrome has been well described in the literature since it was first identified in 1965, the exact cause of this disorder is still unknown and diagnosis is based mainly on clinical features.
Currently, the diagnosis of sIBM is mainly based on clinical features and histopathological analyses of muscle biopsy specimens [26].
The diagnosis of migraine, as proposed by the International Headache Society (IHS), is mainly based on clinical features such as unilateral throbbing headache, hypersensitivity to sound and light, nausea and/or vomiting and focal neurological symptoms (aura).
The diagnosis of PD is still mainly based on clinical features, and a definitive diagnosis can only be confirmed by autopsy findings.
We mainly looked for the clinical features and treatment responsiveness in these patients.
Moreover, CD5-positive DLBCL has been suggested in some studies, mainly from Japan, to have distinct clinical features [ 90].
The diagnosis of tuberous sclerosis is mainly clinical and is usually complicated by varied phenotypic features (Table 1) [ 6]. 'Definite TSC' is diagnosed when either two major features or one major and two minor features are present [ 6]. > Renal lesions are observed in 48 80% of those with TSC and may be in the form of angiomyolipomas (AML), cysts and rarely renal cell carcinoma (RCC) [ 7].
It mainly affects children and, in most cases, its clinical features include mild vesicular exanthema.
