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Prime-boost techniques, which are also being developed to attack malaria, work mainly by stimulating another part of the immune system one that kills infected body cells rather than "naked" pathogens.
Insulin induces the activation of glycogen synthase, mainly by stimulating the dephosphorylation of the serine residues in glycogen synthase that are targeted by GSK3, and stimulates the activation of eIF2B by promoting the dephosphorylation of Ser535.
Fat influences gut microbiota composition mainly by stimulating bile acids secretion.
Cytokinins function mainly by stimulating cell division and growth and by promoting cell differentiation as well (Zurcher and Muller 2016).
Cholera toxin evokes an intestinal fluid secretion mainly by stimulating nervous reflex es) contained within the ENS [11], [13].
GLP-1 receptor agonist exerts glucose-lowering effect mainly by stimulating glucose-mediated secretion of insulin from β-cells.
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Antioxidant properties of Nrf2 are thought to be mainly exerted by stimulating transcription of antioxidant proteins, whereas its effects on ROS production within the cell are uncertain.
Among the three isoforms of NOS, endothelial NOS and neuronal NOS are constitutively expressed, whereas iNOS is mainly generated by stimulated macrophages and its overproduction is associated with the pathogenesis of several inflammation-related diseases, including cancer [ 7].
By stimulating mainly the magnocellular system, peripheral fearful faces would trigger a fast brain response, possibly conveyed by the subcortical colliculo-thalamo-amygdalar route.
We hypothesized in this study that fearful faces unconsciously perceived in the peripheral visual field, by stimulating mainly magnocellular cells, would particularly trigger a fast neuronal response implicating the colliculo-thalamo-amygdalar pathway and then, the frontal cortex.
Because EA mainly achieves its analgesic effect by stimulating the release of opioid peptides, whether SB-334867 blockEA EA in an opioid-dependent way was also studied.
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