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Fibrinogen is a 350-KDa glycoprotein synthesised mainly by liver epithelium, with an important role in the coagulation system.
HA that reaches the systemic circulation is incorporated mainly by liver sinusoidal endothelial cells via a receptor-mediated mechanism [ 13, 14].
In this way, under identical conditions, animal death (mainly by liver hemorrhage) was significantly more prominent in the PTP1B KO mice, together with minimally, but statistically significant higher serum levels of TNF- α in PTP1B KO mice.
Binding of AMP to the gamma subunit in cases of low energy alters conformation and favors phosphorylation of Thr172 of the alpha subunit mainly by liver kinase B1 (LKB1), resulting in a massive increase of enzymatic activity of AMPK.
In a rat model it has been shown that RBC-derived vesicles are rapidly removed from the circulation mainly by liver Kupffer cells and to a lesser extent by other macrophages of the mononuclear phagocyte system through scavenger receptors [ 82].
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Excretion is mainly by the liver, and liver impairment can prolong the half-life, however, without clinical relevance, because of low-activity metabolites.
While IGFBP-3 is mainly synthesized by liver macrophages, IGFBP-1, IGFBP-2 and IGFBP-4, as well as the acid-labile subunit, are mainly produced by hepatocytes (Scharf et al. 1996).
CNTs in vivo can be readily scavenged from blood and mainly entrapped by liver, spleen and lungs.
In mice, nucleotides are mainly cleared by liver [ 32].
Lysozyme is an hydrolytic enzyme mainly produced by liver, the digestive tract and by macrophages [ 5].
Total metastatic formation includes lymph nodes, whereas distant metastatic formation is mainly determined by liver metastases.
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mainly by cancer
predominantly by liver
mainly by hepatitis
mainly by failure
mainly by spleen
mainly by raising
mainly by living
mainly by phosphorylation
mainly by credit
mainly by e-mail
mainly by vaccination
mainly by water
mainly by disproportionation
mainly by pragmatism
mainly by profit
mainly by instruction
mainly by delamination
mainly by surprise
mainly by phone
mainly by word
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