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For all positions, the cap mutations changed Keq mainly by changing ko (resulting in high Φ values).
Furthermore, FGWALP23, as well as its Y5 and W5 cousins, adapts to changes in the lipid bilayer thickness mainly by changing its tilt, with little change of the helix azimuthal rotation.
Mutations at positions α267 α269 significantly changed Keq (indicating a gating motion) mainly by changing the channel-opening rate constant, but had little or no effect on the equilibrium dissociation constant for agonist binding to the C conformation (Kd).
Under floating exchange rates, the adjustment occurs mainly by changing the nominal exchange rate.
With fixed exchange rates, adjustment occurs mainly by changing costs and prices of the myriad commodities that a country produces and consumes.
Second, he intended to stop bleeding jobs, mainly by changing the way the state interacted with businesses looking to relocate or invest elsewhere.
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This corresponds to a range of ambient temperature within which body temperature is mainly regulated by changing peripheral blood flow, with no regulatory changes in metabolic heat production or skin evaporative heat loss.
Fuel efficiency is mainly driven by changing behaviour because of high oil prices, and by new technology that makes vehicles more efficient.
The influences of the deformation on milling force are mainly initiated by changing the actual cutting depth and cutting width.
As disaggregation is mainly triggered by changing environmental conditions, experiments in simplified artificial systems are falling too short to properly address the dynamics of aggregation and disaggregation in real aquatic systems.
Such a tuning is mainly achieved by changing the axial ligands and H-bonding network in the secondary coordination sphere.
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