Upon exposure to a wide range of light regimes, plants show an ability to meet these differing conditions, mainly by alterations in leaf structure and biochemistry (Evans 1989; Niinemets and Tenhunen 1997).
The long-term analgesic and antipruritic effect can be explained by the inhibition of neurogenic inflammatory processes as well as mainly by the alterations in axonal integrity.
When investigating proteome alterations related to development, we found that the observed peak in hippocampus of 2 months old mice was mainly caused by alterations in the proteome of wildtype mice during adolescence.
The p53 tumor suppressor protein is mainly regulated by alterations in the half-life of the protein, resulting in significant differences in p53 protein levels in cells.
It has been suggested that the aging process of the skin is mainly determined by alterations of its dermal stroma consisting predominantly of dermal fibroblasts and the extracellular matrix [ 2, 3].
The signal to change is mainly conveyed by alterations in the patterns of nerve-evoked electrical activity, and is to a large extent due to switches in the expression of genes.
Indeed, several studies recently focused on the detection of such cells, mainly by studying DNA alterations (e.g., mutation, hypermethylation) but also by RNA detection [ 34].
In human skin, it is well documented that exposure to solar radiation, and mainly to the UVA wavelengths, leads to phenotypes of photoaging characterized by alteration in extracellular matrix of the dermis.
Such a conformational alteration is realized mainly by changes in helical tilts (especially that of the cytoplasmic half of helix F) in the late M and early N intermediates, as was observed by neutron diffraction, X-ray diffraction, electron diffraction, and EPR spectroscopy, and most recently by high-speed atomic force microscopy.
These alterations are explained mainly by mechanical factors, as the extra fat load provokes higher work of breathing (19).
