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This important cellular apoptotic process eliminating unwanted or damaged cells that prevents cancer development is mainly activated through intrinsic and extrinsic apoptotic pathways [1] [2].
Obviously, like in BT474, RPS6 was mainly activated through the MAPK pathway.
Oncogenic PIK3CA is mainly activated through gene amplification and "gain of function" single-nucleotide substitution in human cancers [ 27, 28].
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mTOR is mainly activated via the PI3-kinase pathway through AKT/PKB and the tuberous sclerosis complex (TSC1/2).
The c-Jun N-terminal kinase (JNK) pathway is mainly activated by cellular stress and by cytokines that act through several upstream kinases such as TAK1 and TRAF6.
The available adsorption working pairs applied to adsorption refrigeration system, which utilize activated carbon as adsorbent, are mainly activated carbon methanol, activated carbon ammonia, and composite adsorbent ammonia.
These N-alkylnitrosamines were mainly activated by CYP2E1, CYP2A6 and CYP1A1.
Although virB is mainly activated during host infection, it is also activated under in vitro conditions [9].
M1 macrophages are mainly activated by interferon-gamma (IFN-γ).
The novel reporter system showed a strong signal amplification when activated by neuromedin U receptor 1 (mainly activates Gq), neuromedin U receptor 2 (mainly activates Gi) or luteinizing hormone receptor (mainly through the Gs and Gq pathways).
Firstly, through C3b and C4b deposition assays we found that T. cruzi mainly activate the lectin and alternative pathways in non-immune serum.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com