The main underlying pathological pathway for CVD is atherosclerosis, which arises from endothelial dysfunction driven by inflammatory processes.
Depending on the conservation of the underlying pathways, there are two main approaches to studying them in yeast.
However, the region containing the TNFSF4 gene has been found to be associated with celiac disease, a chronic inflammatory disease with a strong immune component [28] and systemic lupus erythematosus, an autoimmune disease [29], which are likely to share common inflammatory pathways with atherosclerosis, the main underlying cause of MI.
However, the underlying pathways of MCLR-induced reproductive system toxicity have not been well elucidated.
It will therefore require a major effort and investment to reveal the nature of these molecules and the underlying pathways.
These terms contain limited information on the underlying pathways themselves.
We determined the underlying pathways by which sunitinib operates as a toxin on gliomas and found vascular endothelial growth factor receptor 2 (VEGFR2, KDR/Flk1) as the main target to execute gliomatoxicity.
Insulin resistance is the main underlying cause of several transcriptionally altered signalling and metabolic pathways in T2D which later lead to defective microvascular, macrovascular and endothelial functions [13].
This operational structure was identified by the WG as the main underlying reason behind the cases where patients failed to be referred properly and be managed within the pathway.
The main underlying action mechanisms of curcumin are probably based on the modulation of multiple important cellular signaling pathways including NF- κB, TRAIL, PI3K/Akt, JAK/STAT, Notch-1, and JNK [ 5, 14].
