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The current study was nested within the main trial, which was conducted from July 2003 to December 2006.
These findings are consistent with the findings from the main trial, which demonstrate low levels of engagement and completion.
None of the schools or teachers who were involved in the feasibility and pilot work was included in the main trial, which is presented in this paper.
However an analysis of the effects of supplementation on broader micronutrient status in this population would have been of interest and is a specified outcome in the main trial, which will be reported elsewhere.
We verified the self-reported Pap test done in Victoria for the main trial, which revealed that the reporting was reliable if the woman was never-screened (i.e. reported no Pap test) or if the last Pap test was in the recent past (data unpublished).
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An executive at one company said a potential snag had been that Erbitux produced at ImClone's factory in Branchburg, N.J., was slightly different from the product used in the main clinical trial, which was made by a contract manufacturer.
This is in agreement with the results of the main MA.17 trial, which showed no difference in hypercholesterolemia rates between placebo and letrozole [ 28].
Participants also completed paper questionnaires as part of the main ACUDep trial, which included established outcome measures of depression; the BDI-II (at baseline and 12 months) and the PHQ-9 (at baseline, 3 months and 12 months after randomisation) [ 25].
(The main trial on which it is seeking approval is for use in patients undergoing orthopedic surgery).
The main trial, meanwhile, which started in September last year, now breaks for the summer and will resume this September when the prosecution and then the defense are due to present their final arguments to the judge, who is expected to give his verdict before the end of October.
The current study highlighted very subtle and important issues that would help improve success of currently ongoing programs and also helped modifications in the design of main CHX efficacy trial which was hence successfully implemented with completion due in next 6 months.
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