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For studies with multiple study reports, we used the main trial report as the primary data extraction source.
When studies included data from multiple publications, the main trial report was used, supplemented by a previous published protocol if available.
Modifications in design related to octreotide LAR toxicity are described in the main trial report [ 15].
Likewise, both the cSLE sub-analysis and the main trial report more effective maintenance of renal remission with mycophenolate mofetil as compared with azathioprine, although this difference was not statistically significant in the cSLE subanalysis (7/8 (87.5%) vs. 3/8 (37.5%), P = not significant)] [ 73, 74].
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Although there are other good examples of this [ 11, 12] in the main, trial reports of the context of the intervention(s) and the evaluation are limited.
As described in the section on the rationale for this study, we began developing it, in line with guidance for complex interventions, in 2006, some five years before the start of the main trial reported here.
Start date: July 2012 Proposed reporting date: July 2015 The main trial paper reporting the effectiveness and trial-based cost-effectiveness analysis will be submitted initially.
An average of 3.1 3.3 calls were provided to patients as reported in the main trial paper, but structured psychological support was not provided.
Future analyses of the main trial will report the impact of averting malaria on the health and cognition of these children.
The main trial publication reported that only one of 296 patients allocated to PI monotherapy experienced a loss of drug options due to protease mutations (identified by local Sanger sequencing resistance tests) likely selected by study drug.
This review will, however, focus on the chemical Cdk inhibitors evaluated in clinical trials to date and will highlight the main trial results reported to date.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com