Sentence examples for main transforming from inspiring English sources

The main transforming genes of HPV 16 and other HR-HPV types are E6 and E7.

HPV E6 and E7 are the main transforming viral proteins that work together to immortalize infected cells [ 9, 10].

The main transforming protein of HTLV-1 is Tax oncoprotein, but recent studies evidence that the basic leucine zipper factor (HBZ) also plays a role in this process (Matsuoka and Jeang 2007).

E5 is the major oncoprotein encoded by BPV-1 and plays a key role in the tumorigenic process [ 13]; the main transforming activity of BPV E5 is due to its specifical binding to PDGF βR, causing receptor autophosphorylation and activation, which results in mitogenic signalling and neoplastic transformation [ 18, 20].

As the main transforming proteins produced by oncogenic HPVs, E6/E7 primarily contributes to carcinogenesis through their modulation of pivotal cell signaling components, including the tumor suppressors p53 and retinoblastoma (Rb).

To define the frequency and spectrum of T-cell responses to HPV16, we used five HPV16 proteins as targets; E6 and E7 are the main transforming proteins and are expressed early in the infection cycle, E4 is an abundant protein that is expressed at an intermediate and late stage, and the capsid proteins L1 and L2 appear at later stages of the life cycle.

We demonstrate that the main transform boundary representing the continental extension of the Romanche Fracture Zone, is actually composed of two distinct margin segments, i.e., the ENE WSW trending sheared margin segment of the Cote d'Ivoire-Ghana Ridge and the NE SW trending rift-influenced sheared margin segment of the Ghana Platform.

These supporting acts can be right up there with the main draw, transforming a barbecue from an unmitigated meat-fest into a well-rounded, nicely balanced meal.

Forest fires are one of the main factors transforming landscapes and natural environments in a wide variety of ecosystems.

Hundreds more have been planted to the east of the capital, all along the motorway and the main roads, transforming what used to be known as "white" Algiers into a huge palm grove.

Public lighting had a decisive impact on Europe's main thoroughfares, transforming them into places where, at least when the weather was clement, people could promenade and shop after dark.