"main transcription factor" is grammatically correct and can be used in written English.
It refers to the primary regulatory protein that controls the transcription of genetic information in a cell. Example: The main transcription factor for the gene encoding insulin is known to be activated by glucose levels in the blood.
Interestingly, data further shows that MGO-induced stress induces the activation of heat shock factor-1 (Hsf-1), the main transcription factor involved in the regulation of the expression of heat shock proteins (HSPs) and cell response to stress.
By using these strains transformed with plasmids containing transcriptional fusions of MLP1, CWP1 and SED1 to lacZ, we were able to delimit the requirement of the CWI MAPK and its main transcription factor (Rlm1) for the observed transcriptional up-regulation.
GAMYB, the main transcription factor that initiates GA signaling, acts as a positive transcriptional regulator of the α-amylase gene in the cereal aleurone during germination (Gubler et al. 1995; Gubler et al. 1999; Gubler et al. 2002; Kaneko et al. 2004).
Recent studies have suggested that NF-κB is the main transcription factor for the inflammatory response mediated progression of diabetic nephropathy.
Recent reports have shown that NRF-1 not only regulate mitochondrial oxidative genes but also controls MEF2A, the main transcription factor for glucose transporter, GLUT4.
As mentioned above, HIF-1 is the main transcription factor regulating the cellular response to hypoxia and its stabilization is known to promote cell survival and tumor progression.
Transcription regulatory elements (REs) bound by transcription factors (TFs) are main players in gene expression (Grünberg and Hahn, 2013).
Main transcription factors acting during their differentiation and function are known, but the behavior and co-operation of these factors still remained unexplored.
Hypoxia inducible factors (HIFs) are the main transcription factors that sense and respond to hypoxia with HIF-1α and HIF-2α being the most widely studied members [191].
In contrast, in IL-16−/− BMDMs, the main transcription factors regulated by T. whipplei were NF-κB, CP2/LBP-1C/LSF and c-Rel (Figure 9B), all involved in inflammatory responses.
Because these stress responses in yeast are controlled by three main transcription factors, Msn2/4 [35], [36], [36], Hyr1 [34], and Hsf1 [37]–[39], we explicitly tested for a putative role of their activation in the inhibition of TOR signaling and rapamycin resistance.
