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The main toxicity observed was nausea and vomiting, myelosuppression was minor.
Persistent thrombocytopenia was the main toxicity observed in these extensively pretreated patients [ 9].
Haematological toxicity, the main toxicity observed in this pretreated population, was mostly severe and persistent thrombocytopenia [ 4, 5].
The main toxicity observed in this cohort was haematological (grade IV) and nausea and vomiting (maximum grade II).
The main toxicity observed was (NCI-CTC grades 1/2/3/4 (n)): Anaemia 23/9/−/−; leucocytopenia 12/7/7/2, diarrhoea 13/15/4/−, nausea/vomiting 9/10/2/−, and increased activity of transaminases 3/3/1/−.
The treatment-free survival (TLS) was higher than a historical control (79% versus 66% at 30 months) and the main toxicity observed was hematologic, but no cases of TLS or TFR were described [ 40].
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The main toxicities observed are given in Table 7 >, scored as worst toxicity per patient.
Regardless of severity main toxicities observed were anemia in 44%, fatigue in 32.4%, and diarrhoea 10.5%.
Regardless of severity main toxicities observed were anemia in 44%, fatigue in 32.4%, diarrhoea 10.5%, nausea 8%, vomiting 5% (Table 3).
Main toxicities observed after 2 cycles of chemotherapy were alopecia (84%), nausea (49%), neuropathy (46%), anemia (33%), lymphopenia (31%), and leukopenia (30%).
The main toxicities observed were neuropathy, myalgia/arthralgia, and fatigue, but events were primarily grade 1 or grade 2. In the adjuvant setting, two phase II studies have demonstrated the feasibility and safety of dose-dense nab-paclitaxel regimens in early BC (Table 3).
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