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The main toxicity encountered was neutropenia which was WHO grade 3 in 11 patients (31%) and WHO grade 4 in seven patients (19%).
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The main toxicities encountered using this docetaxel/cisplatin/UFT/leucovorin combinatorial therapy were neutropenia and nausea and vomiting (Table 3).
As previously reported in the DBCG study, the main toxicities encountered in this phase II study included neutropenia and related events as febrile neutropenia (8% of patients) and neutropenic infection (12%), nausea/vomiting, stomatitis and fatigue.
Cystitis and diarrhoea were the main nonhaematological toxicity encountered during the course of synchronous chemoradiation treatment.
The only grade 3 toxicity encountered was diarrhoea (n=3).
The toxicity encountered was mostly related to the hormonal effects of TAM.
Dose adjustments were made based on the worst grade of toxicity encountered during the previous cycle.
The dose of paclitaxel was adjusted to the toxicity encountered in the previous cycle.
Major toxicities encountered were infective and cardiovascular.
Table 2 shows the toxicities encountered during CAPOX treatment.
Toxicities encountered were classified according to the WHO grading system.
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