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These results demonstrating safety and tolerability of PfCP2.9 formulated with ISA 720 in healthy Chinese adults who are malaria naive are however not generalizable to the main target population of the vaccine, children at risk of malaria.
As infants and young children are particularly susceptible to malaria infection and constitute the main target population for a malaria vaccine, we have evaluated the induction of adaptive immune responses in young children living in malaria endemic regions following vaccination with RTS,S/AS01E and RTS,S/AS02D.
For the purpose of item analysis we selected subjects with arthritis, as this was the main target population for our instrument.
The former decrease is expected, given that sexually active people tended to be the main target population for interventions, whereas the latter increase is somewhat unexpected.
Further work was limited to a smaller number of domains, as our main target population were persons with arthritis and related disorders.
Although the situation varies between the countries, the majority of palliative care services in Europe have cancer patients as their main target population [ 17].
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Main target populations were men who have sex with men (MSM) not using condoms (55%), and serodiscordant individuals exposed to a viraemic partner (45%); PrEP to women for conception, regardless of the viral load of their partner, accounted for 71% (Table 1).
It should be kept in mind that currently the main target populations for adult vaccination (apart from the elderly persons, which are outside the scope of this study) are adults who have medical conditions that place them at risk for complications from influenza and also, in order to limit influenza virus transmission to those at risk in all age groups, health-care personnel or caregivers [ 2].
In the case of Human Immunodeficiency Virus (HIV), quiescent T lymphocytes, besides macrophages the main target cell population in the human body, are readily infected by the virus, however do not support efficient replication due to multiple early post entry replication blocks [1].
CD4+ T lymphocytes represent the main target cell population of human immunodeficiency virus (HIV).
Moreover, human keratinocytes, the main target cell population in epidermal photodamage, irradiated at increasing doses (10, 25, 50 and 100 mJ/cm) were investigated for proliferation, colony formation and induction of apoptosis (TUNEL positivity), respectively.
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