The fact that the telomere association of Polε in rif1 cells, although earlier than in wild-type cells, was not as early as that seen at short telomeres suggests that Rif1 cannot be the sole (or main) target of Tel1 action at short telomeres.
It is accepted that complex I inhibition remains the main target of MPP+ action, but alternative mechanisms like reduction in Δ Ψm (shown here), inhibition of glycolysis, microtubule depolymerisation and oxidative stress may also play part in MPP+ neurotoxicity (Cappelletti et al. 2005; Choi et al. 2008).
However, the membrane seems to be the key determinant of their action, either as the main target of the peptide action or by forming a barrier that must be crossed by peptides to target core metabolic pathways.
Substantive concerns: 1) The main target of MCH neuron action in regulating sucrose vs sucralose preference are unclear, as all photostimulation in the study was directly applied to MCH neuronal cell bodies in the LH.
We hypothesize that this antigen-induced, chemokine-driven recruitment of immune cells into the lymphoid tissue is one of the main targets of Treg action in vivo.
NMDARs are one of the main targets of ethanol action in the brain and, as such, have been implicated in mediating ethanol-associated phenotypes such as intoxication, tolerance, dependence, withdrawal, craving, and relapse [44].
In accordance with value-based management, it is a main target of a company to identify the priority sustainability actions to improve on.
The main target of Boyd's disdain is his rough-edged, latrine-selling father, Mitch Robin Williamss, in his penultimate live-action role), a recovering alcoholic whose poor child-rearing skills still haunt Boyd.
Women are the main target of the regime's brutality.
