Sentence examples for main target genes from inspiring English sources

In this work, we developed 3 plasmid candidate RMs for STEC analysis, containing 3 main target genes respectively: Shiga toxin 1 (Shiga, Shiga toxin 2 (stx2) and flic (h7) [22].

Accordingly to their potent EC50, these compounds induced an efficient protection of hPXR against proteolytic digestion by trypsin even at very low ligand concentrations and were able to induce the expression of the main target genes of hPXR, CYP3A4 and CYP2B6, in primary cultures of human hepatocytes.

p21, a cell cycle inhibitor, and puma, a proapoptosis gene, are two of the main target genes of TAp73.

13 Its main target genes include cell proliferation-associated protein CyclinD1 and antiapoptotic-related protein Bcl-xl.

As shown in Table 3, the main target genes of let-7i-3p miR-154-5p miR-154-5p miR-154-5pP2A2, BDNF, BTG3, ROS, ATG7, and CUL2.

As main target genes of most miRNAs, transcription factors (TFs) have a crucial function in a wide range of biological processes.

These data confirm that TGFβ1 is an EMT inducer and that Twist is its main target gene.

The product of the main target gene of IpsA, Ino1, contains a zinc ion in its catalytic center and needs NAD+ for its reaction [ 30].

That ino1 is the main target gene of IpsA is supported by the observation that the ipsA phenotype was complemented by overexpression of ino1.

We extended our in vitro findings by confirming that collagen synthesis and the main target gene products of this pathway (WNT5A, MMP7) increased in a clinically relevant model of sepsis-induced lung injury and in lungs from patients who died with severe sepsis and ARDS.

Considering that Bmp4 is a main target gene of Fgf10 signaling [ 73, 76- 78], it is currently unclear how Fgf10 might be involved in this process since Fgf10 expression is upregulated in ASMCs and Fgf10 signaling in BASCs is activated after both naphthalene and bleomycin injury [ 54].