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These two major types were NSCLC cell lines that included three main subtypes, namely A549 (adenocarcinoma), COR-L23 (large cell carcinoma), and NCI-H226 (squamous cell carcinoma), as well as a SCLC cell line, NCI-H1688.
Conversely, ER-negative tumors can be divided into two main subtypes – namely those that overexpress (and are DNA amplified for) HER2 and GRB7 (HER2+/ER-), and 'Basal-like' tumors that have an expression profile similar to basal epithelium and express keratin 5, keratin 6B, keratin 14 and keratin 17.
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Esophageal cancers are classified into two main histological subtypes, namely, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC).
An analysis according to the main histological subtypes, namely adenocarcinoma, squamous cell carcinoma and small-cell carcinoma, revealed a statistically significant association for adenocarcinoma, whereas no significant association was found neither for squamous cell carcinoma nor small-cell carcinoma.
The WHO defines four histologic liposarcoma subtypes, namely, well-differentiated, myxoid, dedifferentiated, and pleomorphic [4].
Nodular BPH is categorised into three main subtypes: glandular, stromal and mixed.
Granulosa cell tumours can be divided into two main subtypes, adult and juvenile.
Recently, H3 AIV (one of the main subtypes in waterfowl) has become endemic in chickens.
Using exome and transcriptome sequencing, we identified two main subtypes of renal oncocytoma.
Struma ovarii is one of the main subtypes of ovarian monodermal teratomas (approximately 3%% of all mature teratomas).
A number of investigators have demonstrated the importance of adhesins and there are 2 main subtypes HMW1 and HMW2 [17].
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