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Clinical characteristics of the main study cohort and parameters of disease activity at baseline and after 12 weeks of TNF blockade are summarized in Table 1.
These characteristics were similar to those of the main study cohort, and no significant differences in demographic characteristics at baseline were revealed across the different treatment conditions.
Finally, covariate information from questionnaires routinely distributed at Child Health Care centers was available for 7898 children, which formed the main study cohort.
We evaluated the effects of prenatal methylmercury exposure (through maternal fish consumption) on the age that children walked and first said words in the main study cohort of the Seychelles Child Development Study.
Subjects in the main study cohort were randomized 1 1 1 1 to the ACWY-TT (3 lots) and MenPS groups for the analysis of lot-to-lot consistency and immunogenicity and safety of ACWY-TT vs. MenPS.
The co-primary objectives for the main study cohort were to demonstrate lot-to-lot consistency of the 3 ACWY-TT lots with respect to rSBA GMTs for meningococcal serogroups A, C, W-135, and Y, and to demonstrate non-inferiority of the rSBA VR induced by ACWY-TT compared with MenPS 1 mo post-vaccination.
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We defined the scope of the recommendations to cover three main study designs: cohort, case control and cross-sectional studies.
Its guidelines provide a user-friendly checklist of 22 items to be reported in epidemiological studies, with items specific to the three main study designs: cohort studies, case-control studies and cross-sectional studies.
The main study designs are cohort, cross-sectional or case control.
The search was limited to the following criteria: MAs of the article type and one of three main study designs, including cohort, case control and cross-sectional.
Table 2 Main diagnosis of the study cohort on admission Study cohort (n= 151) Cardiopulmonary diagnosis 67 (44.4) Acute/chronic liver failure 7 (4.6) Acute pancreatitis 5 (3.3) Gastrointestinal disease 8 (5.3) Other intra-abdominal processes 4 (2.6) Acute renal failure 13 (8.6) Cardiac arrest 5 (3.3) Neurologic disease 30 (19.9) Other 12 (8) Values are n (percent).
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