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The phrase "main scientist" is correct and usable in written English
You might use it when you need to refer to an individual or group of individuals who lead scientific research, such as, "The main scientist of the project presented his findings at the conference."
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Comments on CFS-related blogs include outright dismissal ("don't fall for the sweeping conclusions"), attacks on Science for running the report and an accompanying news article ("total crap" and the "National Science Enquirer"), and continued high praise for Judy Mikovits, the main scientist behind the theory ("In Judy We Trust").
Santa (Ken Boynton) – UNITY's main scientist and inventor, he provides Cate with gadgets between the missions.
Mark B. Kristal, the main scientist studying human placenta-eating has not, however, ruled out that there may be benefits to the practice (here's Kristal's recent paper paper on the topic -- it concludes that more research is necessary).
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For example, one of the main scientists whose work is cited as support for the laws is Dr. Kanwaljeet Anand, a professor of pediatrics, anesthesiology and neurobiology at the University of Tennessee's Health Science Center.
In "Paper Clip" one of the main scientists is an ex-Nazi.
Laura Manuelidis, one of the main scientists who rejects the PrP hypothesis, has been portrayed as a "prion heretic".
The chief scientist, and main driver behind the project, Prof Martin Siegert, prepared a few words for on-site cameraman Pete Bucktrout.
The main culprit, scientists say, is agriculture, which has also grown in scale and importance as fishing fades.
Most of the main ones scientists have identified are positive; others are little understood and might go either way.Feedback is the source of the scientists' biggest worry.
The main issue, scientists and climbers say, is that as permafrost, ice and glaciers melt, they leave areas of teetering rock.
The drug didn't do that, and because it failed in its main goal, scientists consider other conclusions from the study as interesting questions, not definitive answers.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com