We correctly identified TFs such as Nuclear Receptors as their main regulators and demonstrated that a gene with unknown function (YEATS2) acts as a negative regulator of hepatocyte metabolism.
This work will provide a framework for constructing miRNA-TF synergistic regulatory networks, function analysis in diseases, and identification of the main regulators and regulatory motifs, which will be useful for understanding the putative regulatory motifs involving miRNAs and TFs, and for predicting new targets for cancer studies.
The aim of this short review is to argue that CR is indeed a regulated process and that its main regulator pathways, mTOR and Sirt-1, are connected to the p53 pathway.
Then, we will discuss literature findings regarding the main regulators Ca2+ and ROS and regarding their effects on apoptosis and necrosis, thus accounting for our modelling decisions.
Elaborate central control systems were devised, with a main regulator, branch mains, secondary regulators, and valves.
Dopamine transporter DAT1 is thought to be the main regulator of synaptic and extracellular levels of dopamine and, consequently, the corresponding gene DAT1/SLC6A3, has been among the most often studied candidate genes in relation to ADHD [ 1].
Nucleocapsid protein (NP) is the most abundant viral protein and the main regulator of virus replication and transcription.
The flexible loop A, loop B and His loop system at the active site is the main regulator of substrate gating and specificity and represents a new inhibitor target.
Habits that ruin sleep often accompany aging: less physical activity, less time spent outdoors (sunlight is the body's main regulator of sleepiness and wakefulness), poorer attention to diet, taking medications that can disrupt sleep, caring for a chronically ill spouse, having a partner who snores.
Vascular endothelial growth factor (VEGF) is the main regulator of physiological and pathological angiogenesis.
