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The phrase "main reason of" is correct and usable in written English.
You can use it when you want to introduce a primary reason for something. For example, "The main reason of its success was the hard work of the team."
Exact(60)
These properties may be the main reason of its cytotoxicity.
the main reason of my coming to this country at this time.
The main reason of the slow IMP degradation was different in strong acidic and basic conditions.
Coke accumulation at high temperature is the main reason of catalyst deactivation.
The decrease of the shielding effects of ground is the main reason of the SFFOR increase.
The main reason of microhardness difference is that two coatings have different solidified structure.
The main reason of deactivation is cross-over of the electrolyte, particularly of K ions.
"The delay of naming security ministers is the main reason of security breaches," Mr. E'laian said.
Infertile women elder 40 name "lack of money for modern infertility treatment" as the main reason of late maternity.
"But the main reason, of course, is that James Fenton is one of the finest poets of his generation".
Variation of the length of CFRP sheet is the main reason of variation of the stress of interface.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com