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Patient population in steps 1 and 2 of this study shared similar characteristic distributions in terms of main prognostic variables.
It is expected that such stratification avoids the imbalance of main prognostic variables between different treatment groups.
A core biopsy of the primary tumour was also performed with the immunohistochemical assessment of the main prognostic variables (steroid hormones receptors, Ki67, HER2/neu).
To anticipate equal distribution of the main prognostic variables over the treatment arms in the subgroups, stratification of randomisation by the subgroup factor is advisable.
The main prognostic variables in early breast cancer are tumor size, histological grade, estrogen receptor/progesterone receptor (ER/PgR) status, number of positive nodes and human epidermal growth factor receptor 2 (HER2) status.
Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12611000506998 The main prognostic variables in early breast cancer are tumor size, grade, estrogen and progesterone receptor (ER/PgR) status, number of positive nodes and human epidermal growth factor receptor 2 (HER2) status [ 1].
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Similarly, respiratory failure and septic shock were the main admission motives, but they were not independent prognostic variables.
For improving predicative accuracy of prognostic systems, new prognostic algorithms have been designed combining independent prognostic variables.
Independent prognostic variables were examined with Cox regression analysis.
Cox regression analysis was performed to identify independent prognostic variables.
A numerical score was derived from the regression coefficients of each independent prognostic variable.
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