However, there are two main problems needing attention if trial participation is to be increased: first that clinicians do not offer trials to all eligible patients (Kaas et al, 2005), and second that some patients offered seemingly appropriate trials refuse participation (Siminoff et al, 2000).
In this paper, the main problem needs to be solved is to alleviate the communication capabilities difference between actors and sensor nodes.
RBP is one of the main problems that need a decision in rail transportation planning, which is made in the tactical level of railroad operation.
Gates sees three main problems which need to be addressed: cost, security, and environmental impact: "Other than it is too expensive, you can get cut off at any time, or it can destroy the planet, it's okay".
Therefore, there are two main problems that need to be investigated when implementing CECGWEP in deep soft coal mines, namely, the technologies for supporting surrounding rock in the retained entryway, and for extracting gas safely.
But, the main problem which needs to be considered in designing an ensemble-based feature selection is diversity [27].
However, the huge computation requirement in global MHD simulations is also the main problem that needs to be solved.
Despite the remarkable advancement in the treatment of HER2-overexpressing breast cancer provided by anti-HER2-directed therapy, especially trastuzumab, treatment resistance remains a main problem that needs to be solved.
"Our main problem is we need more priests," Bishop Sullivan said.
