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A main problem of studies based on self-administrated questionnaires is to correctly diagnose patients with the co-existence of two or more headaches, usually migraine and tension-type headache.
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However, this is a relatively small study although this has been one of the main problems of studies on catatonia.
The main problem of EPC studies likely stems from the absence of a consensus on the surface markers leading to identification of the true population of EPC, as well as a validated and reliable strategy to identify them.
A main problem of previous studies was the management of variations of insulin therapy during follow-up, which becomes more relevant with a longer observation; some studies (2, 4) analyzed baseline therapy, missing relevant information, while another (3) applied questionable statistical models, using therapies during follow-up as if they were baseline variables.
In this section, the main problem of the study is defined.
The main problem of the study was patient recruitment.
A main problem of this study is the deficit of controls.
The main problem of this study is to develop an adequate measure to calculate the similarity matrix containing inter-relationship information between miRNA and gene expression.
The main problem of the study is the difficulty to separate the effects of other sources of pollution based on distance, and the possibility of potential confounding from other sources remains.
The main problems of this study are a relatively small sample size (statistically underpowered), a wide variation in immobilization times, and an inability to monitor concordance to the non weight-bearing protocol.
When Earth, the Moon, and the Sun are considered to be point masses, this particular three-body problem is called "the main problem of the lunar theory," which has been studied extensively with a variety of methods beginning with Newton.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com