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PavMYB10 was identified as a main positive regulator of anthocyanin biosynthesis in the sweet cherry fruit.
The main positive regulator of Abcb11 expression is the transcription factor farnesoid X receptor (Fxr) (Stieger, 2009; Zollner and Trauner, 2009).
GHK also suppresses the production of the inflammatory cytokine interleukin-6 (IL-6) which is a main positive regulator of fibrinogen synthesis, through its interaction with fibrinogen genes [ 18].
On the contrary, the multifunctional transcription factor Runx2, which is expressed in prehypertrophic and hypertrophic chondrocytes, is a main positive regulator of hypertrophic differentiation in late chondrogenesis of the limb buds [ 5, 15, 16].
We speculated that the transcription factor Sox9 may be a main positive regulator in the secondary cartilage terminal maturation, contrary to its function in later differentiation of limb bud cartilage, based on strong expression of Sox9 in the mandibular secondary hypertrophic cell zone.
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Recently, three members SRK2D/E/I were identified to function as main positive regulators of ABA signaling in response to water stress [21].
In Arabidopsis, HsfA1a, HsfA1b, and HsfA1d act as the main positive regulators of heat shock response [ 20].
Consequently, it is suggested that Sox9 is a main and unique positive regulator in the hypertrophic differentiation process of mandibular secondary cartilages, in addition to Runx2.
It is speculated that Sox9 is a main and unique positive regulator in the hypertrophic differentiation process of mandibular secondary cartilages, in addition to Runx2.
To confirm that the data are in agreement with reports in the literature we evaluated the expression dynamics of known key regulators of the transition to flowering and, to this end, the genes for the main negative and positive regulator of flowering (FLC and LFY, respectively) were chosen as reference markers.
Thus, in R. pedestris, which has cry2 [ 7], cyc likely acts as the main positive transcriptional activator and cry2 as the main negative regulator, while per is likely involved in the negatively acting portion of the feedback loop.
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