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We chose PLGA as the main polymer matrix because it is FDA-approved, widely used for a variety of biomaterials applications, and extensively studied as a drug carrier.
The release of small molecule drug from the main polymer matrix can be controlled by the mesh size of the polymer, which is affected by polymer concentration and cross-link density.
In this study, the larger protein molecule, anti-VEGFR-2 antibody, was loaded into the TS channels, while irinotecan was preblended into the main polymer matrix, which consists of high concentration of PEGDA 700.
When the main polymer matrix of PEGDA was cross-linked, anti-VEGFR-2 antibody was encapsulated in empty TS channels, through which the release of anti-VEGFR-2 antibody reached approximately 80% after 3 h.
This suggestion was confirmed by identification of the main polymer matrix by ATR-FTIR combined with the detection of suspected macromolecular contaminants using ATR-FTIR and pyrolysis GC-MS.
Short chain PEGDA was chosen as the material of the main polymer matrix, which only allows diffusion of small molecule drugs and confines macromolecules to the intricate spiral channels.
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Therefore, a successful incorporation of ZnO into a conducting polymer matrix is the main research topic.
The inclusion of the IL in the polymer matrix affected the main relaxation process (β-relaxation) of the amorphous phase of the polymer matrix detected with all the techniques employed.
Bad dispersion, low volume fraction, and poor alignment of long carbon nanotubes (CNTs) in a polymer matrix are the main reasons for the disappointing performance of CNT reinforced polymer composites.
Here we report the successful production of nanofibers from main-chain polybenzoxazines (MCPBz) via electrospinning without using any other carrier polymer matrix.
The main goal of SEM investigation is to give an insight on dispersion of CNTs in polymer matrix and the mechanical mechanism of CNTs in polymer concrete composites.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com