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The phrase 'main point of reference' is correct and usable in written English.
You can use it when you are referring to a primary and/or major source of information or knowledge. For example, "When researching the history of the city, the museum served as our main point of reference."
Exact(11)
It is notable that patients refer to the cardiologist as the main point of reference for their global HF management and do not make use of other sources of information to manage their disease.
Architects are married to an XY (north/south) cartesian grid, with Z (gravity) being the main point of reference for many architectural elements.
For Europeans, the main point of reference is a study completed late last year by the accountants of PricewaterhouseCoopers, which gave some comfort to sceptics and supporters alike.
His main point of reference is a 19th-century Florentine book, Artusi's L'Arte di mangiar bene (The Art of Eating Well).
Politics must be reinvented as the main point of reference of our collective coexistence and not be reduced to the muscleman of capitalism, an institution that simply enforces and legitimises financial decisions and objectives.
Blame the eponymous Mel Gibson movie, for many the main point of reference, in which heroic "diggers" – the nickname was inspired by the Anzacs' trenching achievements at Gallipoli – are sacrificed to Turkish machine guns by monocle-wearing British martinets.
Similar(49)
My main point of contact was Richard Freeman.
When Rahs Move On: RememberItg Jack Wills.
What were the main points of dissatisfaction?
Those are the main points of discussion.
The three main points of contention?
More suggestions(15)
basic point of reference
great point of reference
primary point of reference
main point of democracy
main point of attack
main point of contention
main point of entry
main point of art
main aim of reference
main point of contact
main source of reference
main point of difference
main point of fissure
main point of course
main point of focus
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com