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Subsequently, the main pathways in which the target candidate genes are involved were revealed by KEGG pathway analysis.
To reveal the main pathways in which the target gene candidates are involved, pathway analysis using a major public pathway-related database, KEGG, was performed to identify significantly enriched metabolic pathways or signal transduction pathways in target gene candidates compared with the whole reference gene background.
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Goli et al. argue that low exposure to mass media is one of the main pathways through which inequalities in maternal and child health is perpetuated in urban India (20).
Figure 1 summarizes the main checkpoints and the pathways in which microRNAs are involved in cervical cancer cells.
Within the walls, there are two main pathways which meet in the center of the cemetery at a circular decorative piece including a fountain.
There are two main pathways by which oestrogens can be synthesised in peripheral tissues, that is, the aromatase and sulphatase routes.
There are several main pathways by which signals from the gut travel through the body and cross the blood-brain barrier.
With pathway enrichment analysis, we got the main biochemical pathways and signal transduction pathways in which DEGs involved.
The KEGG pathway enrichment analysis of DEGs was also performed with the whole genome background as a reference to find the main biochemical pathways and signal transduction pathways in which DEGs involved.
The algorithms not only identify the genes of the main pathway, in this case antibiotic biosynthesis, but also genes which are associated with it.
The main pathways which are likely to play a role in the synthesis of prostratin and which were chosen for this study were the Terpenoid Backbone Biosynthesis (TBB) pathway (KEGG map00900) and the Diterpenoid Biosynthesis (DB) pathway (KEGG map00904).
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