The main pathophysiological phenotype of SAKI is tubular damage.
The pathophysiological hallmarks of ARDS are injury to the alveolar epithelial, microvascular endothelial barriers and alveolar-capillary membrane [51], with concomitant activation of inflammatory and coagulation pathways [52].
However, several authors have suggested that, as pathophysiological hallmarks of ARDS, EVLWI and/or PVPI should be taken into account when defining the disease [83 85].
The immune dysfunction is the main pathophysiological process in septic patients.
Figure 2 The main pathophysiological mechanisms involved in acute traumatic coagulopathy and transfusion strategy.
The main pathophysiological mechanisms of the development and progression of parenchymal changes in CVH are inflammatory cell infiltration, necrosis, fibrosis and decreased perfusion of liver parenchyma [10].
The pathophysiology of EM is unfortunately unclear but local primary damage of vascular and neuronal structures has been proposed as the main pathophysiological mechanism underlying it.
HA affects the two pathophysiological hallmarks of AD and may be involved in its etiology.
Amyloid plaques and neurofibrillary tangles are the two pathophysiological hallmarks of Alzheimer's disease (AD).
Further, in adult mice, hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2 pathway [39]; Intrathecal administration of Pam3CSK4 induces the pathophysiological hallmarks of bacterial meningitis and neuronal damage in a TLR2-dependent fashion in adult rats [40].
