Sentence examples for main pathological substrates from inspiring English sources

The identification and characterization of amyloid-β (Aβ) and tau as the main pathological substrates of Alzheimer's disease (AD) have driven many efforts in search for suitable biomarkers for AD.

Multiple sclerosis (MS) is an inflammatory demyelinating disease in which axonal loss (Ferguson et al., 1997; Trapp and Peterson, 1998; Bitsch et al., 2000), thought to be the main pathological substrate for irreversible disability, is the dominant pathological feature of the degenerative phase of the disease (reviewed in (Lassmann et al., 2007; Bjartmar and Trapp, 2001; Esiri, 2007).

Subcortical WM ischemic injury is the main pathological sign of CADASIL, a model of "pure" monogenic small-vessel disease.

The perfect experimental model recapitulating the main pathological characteristics of AD has yet to be engineered, but available models address a number of pathological AD features allowing to translate human markers to mice.

It is widely postulated that the CNS is the main pathological target of GM2 gangliosidosis.

Neuritic plaques, neurofibrillary tangles, and neuronal loss represent the main pathological characters in AD brains.

Emphysema is another main pathological condition for COPD [ 39].

The main pathological subtypes include adenocarcinoma and squamous cell carcinoma.

The main pathological characteristic of BEN kidney is interstitial fibrosis.

The pathological substrates of atrophy on MRI have been more thoroughly studied than for FDG PET.

Vascular remodelling is the main pathological feature in PH and is mediated via vasoactive molecules [ 4].