The main pathological changes are skeletal malformations of the legs, the spinal column and the skull.
Femoral head necrosis and spondylitis were described as the main pathological changes in infected chickens.
The main pathological changes observed in the various organs of the seven necropsied pigs are summarized in Table 1.
In the first 3 weeks post hatch, pericarditis and hepatitis were found as the main pathological changes in 27.6% and 9.8% of the examined broilers respectively.
The main pathological changes within the liver after heavy-metal mixtures administrations marked hepatic damage evidenced by foci of lobular necrosis with neutrophilic infiltration, adjacent to dysplastic hepatocytes.
The main pathological changes are believed to be the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and their terminals in the striatum [ 1, 2].
Autopsy studies have shown that the main pathological changes associated with 2009 influenza A H1N1 infection are located in the lungs, identifying three distinct histological patterns.
In the present study, we showed that aged PGRN-deficient mice presented with increased accumulation of p62 and ubiquitin in the VPM/VPL, where the main pathological changes have been observed in reported NCL model mice [ 15– 15].
No significant alteration in the nerve conduction study was found during oxaliplatin treatment, which may be explained by the fact that the main pathological changes in oxaliplatin-induced neuropathy occur predominantly in DRG[ 18] not sciatic nerves.
The main pathological changes manifest in DN are accumulation of ECM, degeneration of tubular epithelial cells, atrophy, and even the disappearance of some tubules, thickening of basal membranes, and infiltration of inflammatory cells in the mesenchyme [ 21, 22].
