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Notably, our results are not driven by an enrichment of loss of function variants in ABCA7, recently reported as main pathogenic factor underlying AD risk at this locus.
A gain of function polymorphism leading to increased platelet reactivity would likely be more prominent when studied in a setting were platelet activation is a main pathogenic factor, such as AMI.
In conclusion, our data show that HCV infection could be the main pathogenic factor of lichen planus in Japanese patients.
The main pathogenic factor for the development of the infection is the ability of bacteria to form a biofilm.
Such findings suggest that AGEs, the main pathogenic factor of diabetes, may be one of the chief culprits to disturb the M1/M2 ratio.
The amyloid hypothesis is still debated and several arguments point against amyloid as a main pathogenic factor in AD pathology [ 49].
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The mechanisms of main pathogenic factors of Shigella are well stablished; however, studies focusing association between pathogenicity factors and shigellosis symptoms in human are scarce [ 12, 13].
In recent years, research has revealed that the main pathogenic factors in SA-AKI are not hemodynamic failure or ischemia, as previously thought, but inflammation and apoptosis [3].
The main pathogenic factors that induce hepatic fibrosis include chronic hepatitis virus (i.e., HBV and HCV) and parasite infection (e.g., schistosomes), alcoholic liver disease, fatty liver disease, cholestasis, drug-induced liver injury, and autoimmune hepatitis.
The main pathogenic factors of ADPKD hypertension and CV risk are summarized in Table 3.
The decrease in the number and function of EPCs may be one of main pathogenic factors of MODS.
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