These findings indicate that the 2 diseases may show more commonality than previously recognized, with dysregulation of the alternative pathway playing a primary pathogenetic role.
This suggests that the independent pathogenetic role of low-dose aspirin use, if any, may be minor on the risk of incident gout.
Ischemia, reperfusion injury, and endotoxemia were the main pathogenetic mechanisms in SU formation.
One of the main pathogenetic mechanisms underlying cancer cachexia is a complex interaction between the host and the tumour.
The main pathogenetic event in TSEs involves the trans-conformation of PrPC to PrPSc, which leads to the accumulation of detergent-insoluble and partially protease-resistant aggregates.
Since the principal pathogenetic mechanisms for diabetic retinopathy (DR) and PDR are different, the main pathogenetic mechanism in DR is increased vascular permeability, whereas in PDR the crucial pathogenetic mechanisms are fibrosis and neoangiogenesis.
In the following review, we will describe the main pathogenetic links between AKI and CKD and introduce some potential key players.
Acne has four main pathogenetic contributors: follicular hyperkeratinization, increased sebum production, Propionibacterium acnes (P. acnes) within the follicle, and inflammation.
The main pathogenetic factors of FD include genetic predisposition, psychosocial factors, infection from Helicobacter pylori, and inflammation [ 6, 7].
Epithelial cell apoptosis involves and is considered to be among the main pathogenetic mechanisms in the development of any DAD [ 51, 52].
