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Baseline patient characteristics, PARDS data (for a period of 72 h), RBC transfusion characteristics, and main outcome data in the PICU were retrospectively collected in the electronic medical records.
Three withdrew and 27 were lost to follow-up, leaving 528 (94.6%) with main outcome data.
The main outcome data in the efficacy studies were changes in HbA1c at study completion.
We calculated 95% confidence intervals (CI) for the main outcome data.
To decrease response bias in either trial arm, the main outcome data was defined as a record of screening in the primary care notes, rather than self-report.
For the purposes of the current paper, we assessed domain V as 'No' (high risk of bias) if the main outcome data were not extractable for meta-analysis.
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The subgroup analyses of the sampling fraction, study design, study period and the proportion foreign-born did not reveal any significant effects on the main outcomes (data not shown).
Per protocol analyses of the primary outcome data replicated our main results, except for the plasma vitamin C level for which the increase over 12 months was slightly greater in the comparison than in the intervention group (p = 0.04).
Data collected were baseline and follow-up data for the main outcome, randomised allocation data, preference data, and demographic data.
Main Outcome Measures: Data were collected immediately after runs of 10km or 20km.
Main Outcome Measures: Data comparing persons entering treatment with those not entering treatment were retrieved from summary admissions reports.
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