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His main obstacle used to be resistance from the Kurdish side.
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In a case study of the use of guidelines and protocols in a prehospital organization, the format of the guidelines was the main obstacle to using the guidelines.
The main obstacle to using UAAs to generate ADCs seems to be the initial investment required to express the requisite UAA-containing antibodies; in contrast, other methods can be used with native antibodies or those with just a few mutations.
However, the main obstacle for using this technique on large-scale assessment data is the difficulty in finding proper IVs.
That is the main obstacle for using conductive copper ink because the appearance of copper oxide will result in decreasing the electrical conductivity.
In fact, the main obstacle in using such complex and massively parallel DSP processors is the fact that the compilers available today cannot fully exploit the architecture and at the same time achieve efficient code for SDR.
The main obstacle to using mineralized human solid and liquid wastes as a source of mineral elements for plants cultivated in bio-technical life support systems (BLSS) is that they contain NaCl.
Apart from the fact that such a model would be extremely complex (high model complexity is often regarded a main obstacle of using population models in risk assessment [12]), such a 'meta-model' would usually go hand-in-hand with increased uncertainty [10].
Urquhart [ 2] claims biological variability in drug response to be the main obstacle to using biological markers for adherence.
In many practical applications the space requirements are the main obstacle for using a dynamic programming algorithm.
As in other work, the main obstacle to using EBP lay in "a lack of research skills" [ 6– 10].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com