Sentence examples for main negative regulators from inspiring English sources

In this issue of Cancer Cell, Gannon and colleagues create genetically engineered mice to test the role phosphorylation plays in the modification of one serine long thought to play a critical role in controlling the activity of MDM2, one of p53's main negative regulators.

In addition to the amplified activation of PI3K/Akt pathway, many cancer cells including breast were reported to have deletion or mutation of PTEN, one of the main negative regulators of the PI3K/Akt pathway.

In renal carcinoma cells lacking VHL protein, the main negative regulator of HIFs, HIF1 negatively regulates mitochondrial biogenesis and oxygen consumption by inhibiting the activity of c-Myc [195].

Thus, in R. pedestris, which has cry2 [ 7], cyc likely acts as the main positive transcriptional activator and cry2 as the main negative regulator, while per is likely involved in the negatively acting portion of the feedback loop.

Loss of VHL, the main negative regulator of HIFs, led to lethal CTL-mediated immunopathology during chronic infection, and VHL-deficient CTLs displayed enhanced control of persistent viral infection and neoplastic growth.

One notable distinction between conventional T cells (Tconv cells) and Treg cells is differences in the activity of phosphatidylinositol-3-OH kinase (PI(3 K); only Tconv cells downregulate PTEN, the main negative regulator of PI(3 K, upon activation.

Initially, RasGAP has been identified as the main negative regulator of Ras, since its C-terminal GAP domain catalyzes the hydrolysis of GTP-bound Ras to GDP-bound Ras.

PTEN is the main negative regulator of the phosohatidylinositol-3-Kinase (PI3K) signalling pathway.

MDM2 is the main negative regulator of p53 activity and stability [ 75].

PTP1B has been identified as the main negative regulator of insulin signaling.

PTEN is the main negative regulator of the phosphatidylinositol 3 kinase/Akt pathway [ 19].