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However, fluorescence quenching by metallic particles is the main negative factor.
As found in all oral health quality of life studies, the main negative factor for oral well-being was dental pain ("impact value").
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In our study, a higher plasma concentration of lactate represents the main negative prognostic factor, as pointed out by other studies [ 5].
This event, considered the main negative prognostic factor in patients with HCC, represents the final outcome ensuing from the direct invasion of the portal vein and the production by neoplastic cells of pro-coagulative cytokines [ 16].
It could be an indicator of HUS complicated with MOF and, therefore, one of the main negative prognostic factors.
The main negative prognostic factors in the present study were older age, male sex, diabetes mellitus, and dementia.
Even though spontaneous regressions have been sometimes described in patients with HCC [ 11, 12], the present case seems definitely unusual since it occurred in an elderly patient with infiltrating disease and portal thrombosis which, as it is well-known, represent the main negative prognostic factors for HCC.
"Bowie Kuhn was a negative factor for baseball," Miller said.
"It's been a big negative factor for me".
Its main negative impact will be on population size.
According to the Visit Guatemala Flash Report in the Investigations of Market Section of Statistics: "The main indicators for measuring tourism in Guatemala show that despite the negative factors affecting the sector worldwide (economic crisis, unemployment, etc).
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