Driver mutations have been the main molecular targets to be tackled with "smart" drugs, thus providing the rationale for precise medicine.
Besides these two main molecular targets for cell death imaging, several other approaches are also being evaluated as (surrogate) markers of cell death.
Proteins are one of the main molecular targets of age-related oxidative stress, which have been observed during aging process in cellular systems.
In this review we discuss some of the main molecular targets related with tumor cell proliferation and migration as well as their potential contributions to radiation oncology improvements.
Despite the previous finding describing the role of silibinin, the main molecular targets responsible for its strong antimigratory and anti-invasive efficacy remained inconclusive.
Two main molecular targets have been explored in the amplification of the parasite DNA by qPCR: the minicircle k-DNA [ 30] and the satellite DNA [ 31].
Even though the Nrf2 pathway was identified as one of the main molecular targets of SWT, it is well known that therapeutic effect of many herbal medicines can be attributed from targeting multiple rather than single molecular targets.
Although there are various reports about curcuminoids as the main molecular targets of Curcuma species, other constituents can be considered unique or coadjuvant molecular target of the curcuminoids in different therapies [ 24].
To understand biological function or molecular mechanism of the main molecular targets of MSTN, we used a set of bioinformatics web tools such as Genomatix, DAVID and PANTHER for gene identification and String for interactions networks between proteins.
NF-κB, one of the main molecular targets of chemopreventive phytochemicals [ 31], is a transcription factor involved in multiple cellular processes, including cytokine gene expression, cellular adhesion, apoptosis, and metastasis [ 32].
