We analyzed miRNA expression in human HCC samples to identify molecular subclasses and oncogenic miRNAs.
Analysis of gene expression profiling data on breast cancers has revealed "molecular subclasses" that may have prognostic significance.
Among the 10 most cited articles, 7 reported on genomic analyses, molecular subclasses of glioblastoma and/or stem cells.
The "basal-like" breast cancers, one of these molecular subclasses, have been associated with a significantly worse overall and disease-free survival as compared with most of the other subclasses.
Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD, Misra A, Nigro JM, Colman H, Soroceanu L, Williams PM, Modrusan Z, Feuerstein BG, Aldape K (2006) Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.
We will discuss whether studies should be done in the overall, unselected breast cancer population or in specific homogeneous molecular subclasses.
Imaging can be used to determine the molecular diversity of disease and thereby stratify patients into molecular subclasses with different prognoses [72].
The effect of weight loss on specific plasma lipid molecular subclasses is not well understood.
These results strongly suggest the existence of molecular subclasses for the FTA and FTC -samples.
Thus, gNMF classification defined three stable molecular subclasses among the metastatic samples.
