Sentence examples for main molecular pathways from inspiring English sources
Two main molecular pathways lead to caspase activation and therefore to apoptosis the so-called extrinsic and intrinsic pathway.
The main molecular pathways of cellular senescence, the p53- and p16-pRb- pathways, are activated in fusion induced senescent (FIS) cells.
The integrated analysis resulting from KEGG and Biocarta databases allowed us to identify the main molecular pathways altered in BC cell lines after hypoxic exposure for 24 h and 48 h.
After hypoxia for 24 h and 48 h, the following main molecular pathways were found altered in BC cell lines: DNA damage repair, cell cycle regulation, HIF-1 α network, and mitosis control.
Two main molecular pathways implicated are Src/PI3-Kinase/Akt and Src/Ras/ERKs, which subsequently may activate NOS, as well as other enzymes (Alexaki et al. 2004; Cardona-Gómez et al. 2003; Guerra et al. 2004; Migliaccio et al. 2002; Viso-Leon et al. 2004).
In the clinical practice, advanced NSCLC can be treated with cytotoxic chemotherapy in combination with targeted agents that block two main molecular pathways: cell signaling mediated by the epithelial growth factor receptor (EGFR) and angiogenesis mediated by the vascular endothelial growth factor (VEGF).
The mitogen-activated protein kinase (MAPK) signaling cascade is the main molecular pathway that is deregulated in pilocytic astrocytomas [ 56].
The incidence of HCC shows clear geographical variation with higher annual incidence in Asia and Africa than in Western countries; we aimed to review the literature to find if there are different trends in the main activated molecular pathways.
Cluster 1 significantly (P < 0.05) defined 6 biological processes, 5 predominant molecular functions, and 1 pathway, whereas the 66 genes in cluster 2 clearly involved 6 biological processes, 7 main molecular functions, and 2 pathways (Table 1).
The main functional categories and molecular pathways of the genes that were over-expressed in the Glud1 mice were those of cell responses to oxidative stress, cell injury, and inflammation, as well as those of nervous system development, neurite growth, and synaptic transmission.
Weighted Gene Analysisssion NetWGCNAAnalysis (wasNappliedapplied to genes with highly variable expression at 2 and 4 months to identify novel modules of genes with co-expression and summarize the main enriched biological functions and molecular pathways that are disrupted at these early stages in TASTPM mice.
