A systematic genetic screen by RNA interference has discovered the stromal interaction molecule (STIM1) and ORAI1 (also termed CRACM1) as the main molecular components of CRAC channels (Liou et al, 2005; Roos et al, 2005; Feske et al, 2006; Zhang et al, 2006; Vig et al, 2006b; Hogan et al, 2010).
We were able to build FIRM based on a reconstructed network of the main cellular and molecular components involved in the immune response.
What are the main metabolic pathways, molecular components and their relation to oncogenic Ras pathway, which are taking part in metabolic addiction of pancreatic cancer cells?
A graphical sketch of the main molecular interactions among the BCC components is given in Figure 1.
The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and cannabis active components, is the most abundant G protein-coupled receptor in the mammalian brain.
Alternatively, CD151 may act through laminin-binding integrins, its main molecular partners in tetraspanin microdomains, by strengthening interactions of endometrial cells with laminin components of the basement membrane.
Here we sought to systematically evaluate the basic molecular components and main pathways that govern and mediate cellular response initiated within human CD34+ cells to etoposide-induced apoptosis.
Most importantly there is a lack of knowledge about the molecular components of early progression and metastases, which are two main reasons for the overall poor prognosis.
The attribution of each of the molecular components to each of the pathways is probably now the main challenge.
