An imbalance between oxygen demand and supply, bleeding episodes due to invasive procedures and anticoagulation, inflammation, hemodilution, and kidney failure are the main mechanisms linking anemia and coronary heart disease.
No further protein has been added to the list since then, suggesting that redox modifications of proteins – although reasonably proposed as likely modulators of autophagic signal transduction – are not the main mechanism linking ROS and autophagy.
30 From a mechanistic standpoint, it is difficult to discern whether the main mechanism linking T2DM to AD is glycemia, hypertension, insulin resistance, or factors specifically related to adipose tissue.
The main mechanism linking folate deficiency to DNA damage is presumed to be the incorporation of dUMP into the DNA, which is thought to culminate in futile cycles of uracil excision, single-strand breaks, and possibly chromosomal breakage (Blount et al, 1997).
The two main mechanisms that link mitochondria to ageing are the mutagenesis of mitochondrial DNA (mtDNA) and the production of reactive oxygen species (ROS).
One of the main proposed mechanisms linking vitamin D with renal-vascular and kidney disease is regulation of the renin-angiotensin system (RAS) [ 8, 9].
The mechanisms involved in the potential toxic effects of in-home solid fuel exposure-related cardiovascular system are unclear, but the main mechanisms may be linked to inflammation through the generation of reactive oxygen species (ROS) and oxidative stress.
We tested two main concepts about mechanisms linking LULC and lake water chemistry: groundwater pathways are an important mechanism driving legacy effects; and, LULC over multiple spatial scales is more closely related to lake chemistry than LULC over a single spatial scale.
Adipokines and cytokines participate in the main pathophysiological mechanism linking obesity, IR, T2DM, and atherosclerotic disease [ 58, 59].
It has been hypothesized that increased systemic inflammation a risk factor for, as well as a consequence of, atherosclerosis is the main underlying mechanism linking long-term PM exposure to incidence of CVD (Brook et al. 2010).
