Using temporal expression-profiling by microarrays and qRT-PCR, we characterise this response in the main amphibian lymphoid tissue, the spleen.
Antigen-presenting immune cells found in mucosa, skin and lymphoid tissue whose main function is to activate lymphocytes and secrete chemokines.
(3) Does ectopic lymphoid tissue represent the main priming site of auto-reactive B cells? (4) Does ectopic lymphoid tissue formation contribute to characteristic peripheral B-cell disturbances caused by the underlying disease?
For example, inulin or FOS consumption can increase lymphocyte numbers in the Peyer's patches of female rodents under healthy and endotoxemic conditions, indicating an impact on the main inductive portion of gut-associated lymphoid tissue (GALT) in the small intestine [ 34, 35].
Primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma is an extremely rare disease.
Thus, while B cells are the main site of MuHV-4 latency in lymphoid tissue [27] with a well-established role in virus transport [28], stromal infection may also play a fundamental role in the viral lifecycle [26], [29], [30].
Latent reservoirs including resting CD4+ T cells, monocyte/macrophage lineage, microglia, and gut-associated lymphoid tissue macrophages are the main obstacle in the race for a cure of HIV-1 infection.
We hypothesize that this antigen-induced, chemokine-driven recruitment of immune cells into the lymphoid tissue is one of the main targets of Treg action in vivo.
The observations of interactome network connectivity changing with age made in the main lymphoid data set were also seen in brain tissue where adult samples were also available (Additional file 2: Figure S6).
We were able to analyse network connectivity across all age groups in both the main lymphoid data set and in temporal lobe brain tissue; this was highest in infancy and reduced to final height in both data sets.
