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The phrase "main issue is that" is correct and usable in written English.
You can use this phrase to refer to the primary problem or obstacle that needs to be addressed. For example: "The main issue is that the current healthcare system is unsustainable for our growing population."
Exact(58)
The main issue is that the judges would have anonymity.
The main issue is that kafala restricts labour mobility.
The main issue is that of "burden-sharing".
"The main issue is that the investment needed to develop the mine is huge," he said.
The main issue is that it doesn't know what it is.
But the main issue is that, on ski holidays, there are always too many people about.
But the main issue is that, like many such dams, the project shouldn't exist in the first place.
The main issue is that the markets are not set up to trade or finance defaulted Treasuries.
The main issue is that of improving access to expensive patented medicines for AIDS, malaria and tuberculosis for countries that cannot afford them.
Sarah von Himmelheim initially had a few doubts: "My main issue is that the characters of Susan and Colin remain so empty and lifeless.
Similar(1)
One of the main issues is that PWMs defining TF binding sites are usually short and quite degenerate, meaning that the matrix will match at many "false positive" locations in addition to true binding sites.
More suggestions(15)
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main difficulty is that
main cause is that
principal issue is that
main problem is that
fundamental issue is that
main themes is that
main difficulties is that
core issue is that
main reason is that
main idea is that
main assumption is that
main finding is that
main conclusion is that
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com