Sentence examples for main hydroxylation position from inspiring English sources

The main hydroxylation position of CYP106A2 is thought to be influenced by the functional groups at C3 position in the steroid core leading to a favored 15β-hydroxylation of 3-oxo-Δ4-steroids and 7β-hydroxylation of 3-hydroxy-Δ5-steroids.

Following re-extraction and quantitation (Table 2), it appeared that NU7199 was the most prevalent of the two metabolites (10% in both plasma and urine), thus suggesting that the main hydroxylation position is the 2 position of the morpholino ring.

The metabolites M2, M3, and M4 (hydroxyl-Pd-la), as minor metabolites, were unlike in the hydroxylation position in the Pd-la molecule.

In addition, we detected hydroxyphenyl phenyl phosphate – hydroxylation position unconfirmed – in our participants despite not being identified as a major metabolite in vitro.

The first step towards activation takes place in the liver and is hydroxylation at position 25, this is followed by hydroxylation at position 1, which primarily takes place in the kidneys and is mediated by the enzyme 1α-hydroxylase.

The degradation of these compounds has revealed two main processes: hydroxylation and oxidation of the aromatic system.

This was facilitated by the CN substituent blocking C-8, in contrast to F-5 of enrofloxacin (Wetzstein et al. 1997) or ciprofloxacin (Wetzstein et al. 1999), for which hydroxylation of position C-5 was indistinguishable from hydroxylation of C-8.

Degradation routes were initiated by oxidative decarboxylation (A), defluorination (B), hydroxylation of position C-8 (C), and decomposition of the amine moiety (D) which, alternatively, could be eliminated intact as F-10.

They are normally locked in the main line "running" position.

*Exclusively in Main Position.

Structurally, apimaysin and maysin are highly related and differ only by B-ring hydroxylation in position 3' [ 47, 48].