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The main hurdle that has hindered the development of antimicrobial peptides is that many of the naturally occurring peptides (such as magainin), although active in vitro, are effective in animal models of infection only at very high doses, often close to the toxic doses of the peptide, reflecting an unacceptable margin of safety.
The main hurdle that needs to be overcome in order to use γδ T cells as a therapeutic is obtaining these cell in clinically meaningful numbers.
They hoped that the macabre musician could find a creative solution to Gladiator 2's main hurdle – that Maximus, Crowe's character, dies at the end of the first film.
"The main hurdle that young scientists face is getting their work noticed," he says.
Nevertheless, low transduction efficiency remains the main hurdle that hinders further clinical applications.
Similar(55)
The main hurdle is that language skills — good Mandarin, in particular — have become more and more of a "must" for white-collar jobs here.
But the main hurdle was that Allynne had never before been with a woman, and it took her a while to recognise her feelings.
The main hurdle is that experts cannot determine the actual state of the brain after the fact, only whether a person has a propensity for partial arousals.
The main hurdle is that the PCIe slot isn't integrated into most current motherboard designs, so it'd have to become a standard present in future products.
However, such studies will not be trivial, as jakobids are difficult to culture, and no protocols are yet available for isolating pure and intact mitochondria from these organisms (the main hurdle being that the organelle is firmly integrated with other subcellular structures [ O'Kelly 1993]).
For Hurdle, that was the moment.
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Justyna Jupowicz-Kozak
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