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The main genes studied in relation to dyslipidemia are those that encode proteins, receptors, and enzymes related to lipid metabolism and regulation.
Authors have provided highly accurate gene data for a large fraction of papers, resulting in valuable links between recently published papers and the main genes studied in them on the FlyBase website.
Skim curation has two aims: first, to curate a limited amount of data (identifying the main genes studied in the paper and recording if an antibody has been generated), and secondly, to record the types of data contained within the publication using a defined set of 'flags' (Table 1).
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The main candidate genes studied within the serotonergic system are those coding for the serotonin transporter (5- HTT/SLC6A4), the 1B and 2A serotonin receptors (HTR1B) and (HTR2A) and the dopamine decarboxylase (DDC) and tryptophan hydroxylase (TPH2) genes.
For genes studied, see Text S1.
It is crucial to study the main genes involved in the vernalization and photoperiod pathways simultaneously, because this enables the interactions and functions of these genes to be interpreted more accurately, and their involvement in the induction of flowering to be elucidated.
In the remainder of this article, we review the main candidate gene studies which have arisen primarily from analysis of folate metabolic pathways and mouse models of NTDs.
A recently published whole genome association study confirms that the main genes important in warfarin response are CYP2C9 and VKORC1.
By studying the process in yeast cells, Ohsumi identified the main genes involved in autophagy and showed how the proteins they code for come together to build the autophagosome membrane.
Previous studies have demonstrated that bch and bkt are the main genes involved in astaxanthin biosynthesis [ 89].
These gene families have members located in overlapping regions of the human genome putatively considered as one paralogon and are henceforth referred to as the "main" gene families of this study.
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