Sentence examples for main gene targets from inspiring English sources

The output of these cascades entails the selective activation of transcription factors whose main gene targets code for components of the ER protein-processing machinery [3].

Then, we validated the main gene targets of this pathway in a clinically relevant murine model of sepsis-induced ARDS by cecal ligation and perforation (CLP), and in lung biopsies obtained from patients who died within the first 24 h of septic ARDS.

We examined changes in protein levels of target genes involved in the Wnt pathway, including WNT5A, non-phospho (Ser33/37/Thr41) β-catenin, matrix metalloproteinase-7 (MMP7), cyclin D1, and vascular endothelial growth factor (VEGF) by Western blotting and immunohistochemistry. Finally, we validated the main gene targets of this pathway in experimental animals and human lungs.

In order to determine the HIV subtypes and resistance-associated mutations in protease (P) and reverse transcriptase (RT) coding regions, pol gene targets of the main ARVs, were amplified by the French National Agency for AIDS Research consensus polymerase chain reaction (PCR) technique (AC-11 Resistance Group, http://www.hivfrenchresistance.org).org

Following infection, an initial phase of B-cell activation and proliferation is driven by viral genes and orchestrated by the viral TCF Epstein Barr nuclear antigen (EBNA -2.92 Significantly, onEBNA -2.92ain cellular geneSignificantly EBNA-2 fonethis purpofe is c-MYC.

The main outcome measures were positive PCR by one or more gene targets, and factors influencing positive PCR outcomes.

Drugmakers are awash in potential gene targets.

There are three main approaches to transfecting cells for gene targeting: chemical, electroporation and viral.

These data confirm that TGFβ1 is an EMT inducer and that Twist is its main target gene.

The product of the main target gene of IpsA, Ino1, contains a zinc ion in its catalytic center and needs NAD+ for its reaction [ 30].

That ino1 is the main target gene of IpsA is supported by the observation that the ipsA phenotype was complemented by overexpression of ino1.