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The method is not only able to predict and reassign the function of a given protein, but also to describe qualitatively the main functional interactions that lead to the global functioning of the organism.
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Three main classes of functional interactions (co-expression, perturbation and genetic interactions) have extensive measurement coverage in yeast.
These differentially expressed genes were mapped to their main functional process, while interactions were extracted from multiple data sources using String 8.0 [ 25].
As our main focus is on functional interactions, we additionally derive link descriptors from the node-based STMs.
Therefore an interaction with the CRD may be the main functional site for Groucho binding, but auxiliary interactions with the HMG DNA binding domain might further stabilize the complex.
Here, I provide an overview of the most recent developments in the field, with a focus on main functional groups of insects, but also their interactions with other organisms.
At least 14 length-deviant domains are involved in regulatory processes and others are involved in structural roles where protein-protein interactions would be the main functional theme.
We describe the main functional blocks of the hardware accelerator and their interactions, and comment architectural solutions we adopted for maximizing security and performance while minimizing the cost in terms of hardware resources.
The inhibition of protein interactions, such as receptor-ligand interactions or the interplay during pathogen infections, is one main functional principle of therapeutics to influence biologically relevant processes.
Interestingly, the interaction network was clustered again in the three main functional nodes (cell wall and morphogenesis, signal transduction and transcription) described above.
We investigated PRDM5 function by identifying its target genes in U2OS cells, and we found that the two main functional categories of genes regulated by PRDM5 are molecules involved in cell-cell interactions and components of developmental signaling pathways.
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