Its main features involve: (i) a clear magnesium-binding site; (ii) an alpha-helical conformation for the so-called LID region; and (iii) a high density of positive charges in the active site.
Several changes in morphology and gene expression profiles have been observed in follicular thyroid cancer cells, grown under s- μg conditions with the main features involving changes in the ECM and early induction of apoptosis [ 39, 40].
The main vascular pathological features involve sclerotic changes in intracranial arteries and arterioles, whereas parenchymal lesions in the subcortical structures largely involve lacunar infarcts, microinfarcts, increased perivascular spacing and deep white matter (WM) attenuation (Table 1).
Table 3 compares NB classifiers based on only main factors (and thus using association scores) with those utilizing both main factors and selected features involving cofactors.
(Note that a feature type is defined by w = 2, 1, 0, the number of main factors in a TF combination as presented in the last section. For example, features involving two main factors are one type of features).
Although features involving two main factors and one cofactor are not selected for other clusters, the two ES-down features for the Oct4 cluster are of this type.
In addition, except the Oct4-moderate cluster, there are features involving one main factor and one cofactor in all the other clusters.
Depending on main factors of interest in a cluster, features involving TF combinations constructed in different clusters are different.
In the current framework, we consider features involving only one cofactor and up to two main factors.
